Lorenzo Scalise turned professional in 2018, following on from his win at the 2017 Italian Amateur Championship and Low Am honours at the 2017 Italian Open. He sealed his maiden professional win at the 2019 New Giza Open and his first Challenge Tour victory at the Kaskáda Golf Challenge in June 2023 by 3 shots. Thanks to a series of top 4 finishes, Lorenzo finished the season ranked 7th on the Road to Mallorca rankings and secured his DP World Tour card for 2024.